The genes are not to blame

Individualized dietary suggestions based upon hereditary details are presently a popular pattern. A group at the Technical University of Munich (TUM) has actually methodically examined clinical short articles and reached the following conclusion: There is no clear proof for the impact of hereditary aspects on the usage of overall calories, carbs, and fat. According to the existing state of understanding, the expedience of gene-based dietary suggestions has yet to be shown.

Overweight and weight problems have actually ended up being an international health issue. According to the World Health Organization, 39 percent of grownups in EU nations have obese. In Germany more than 50 percent of grownups struggle with obese, practically one fifth is according to the Robert Koch Institute presently thought about overweight. This is mostly due to the contemporary way of life which is identified by low exercise and high-calorie foods.

Also hereditary aspects contribute in the event of weight problems. To date, around a hundred genes (loci) have actually been recognized which are associated to the body mass index (BMI). However, the performance of these genes along with the biological systems behind them are still mostly unidentified. The examination of the relationship in between hereditary aspects and nutrition can clarify whether the genes which are connected to BMI contribute in nutrition.

Systematic literature search

The preliminary database search of the TUM group exposed more than 10,000 clinical short articles which were interested in the subject. Of these, 39 short articles were recognized for a relationship in between hereditary aspects and overall energy, carb, or fat usage. “In all studies, we most frequently encountered the fat mass and obesity (FTO) associated gene as well as the melanocortin 4 receptor gene (MC4R). There are indications of a relationship between these two genes and total energy intake,” discusses Christina Holzapfel, PhD, from the Institute of Nutritional Medicine at TUM.

However, the assessment of the research studies did not supply a consistent image: “There is only limited evidence for the relationship between the FTO gene and low energy intake as well as between the MC4R gene and increased energy intake.”

Hence,to date there exist no signs that specific hereditary aspects are connected with the overall consumption of calories, carbs, and fat. The existing state of understanding is still too minimal for obtaining specific dietary suggestions based upon hereditary details, e.g. for weight management, discusses the scientist. Expert associations likewise concur with the latter declaration.

“Human studies with detailed phenotyping, e.g. based on a genetic pre-analysis of the participants, are necessary in order to determine the interactions between genetic factors and diet on body weight. The “PersonalizedNutrition & & eHealth” Junior Research Group funded by the Federal Ministry of Education and Research, which is part of the enable nutrition cluster, is working precisely on this.”


More details:

The interdisciplinary make it possible for cluster is among 4 nutrition research study clusters moneyed by the Federal Ministry of Education and Research (BMBF) and based at the Weihenstephan Science Centre of the TUM inFreising make it possible for establishes brand-new techniques to feed individuals in various stages of life more healthily – from birth to aging. More aboutDr Holzapfel’s group:


TheresaDrabsch, Jennifer Gatzemeier, Lisa Pfadenhauer, Hans Hauner, Christina Holzapfel: Associations in between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review, Advances in Nutrition, Volume 9, Issue 4, 1 July 2018, Pages 425-453,


Dr rer. nat. Christina Holzapfel .

TechnicalUniversity of Munich .

NutritionalMedicine .

Phone: +49/89/289249 23 .

Mail: [email protected] .

Disclaimer: We can make errors too. Have a great day.

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