Experiments of the Russian scientists in space lead to a new way of 3D-bioprinting

Thanksto the research study of magnetic levitation in the conditions of microgravity, a new technology for 3D printing of biological tissues was established. In the future, this technology will assist to produce radiation-sensitive biological constructs and fix broken tissues and human organs. The outcomes are released in Biofabrication The technology is based upon the results of the speculative research studies which were supported by Russian Science Foundation (RSF). .

There are lots of approaches of3D-bioprinting Most of them utilize a particular layer-by-layer structure of the biological tissues. The resulting bulk product is then sent out to the incubator where the growing continues. There are methods in which biological things are established without the usage of multi-layer technique, for instance, magnetic bioprinting, when the cell product is directed to the wanted place by ways of the electromagnetic fields. In this case, the cells ought to be identified in some way with magnetic nanoparticles. .

The scientists from the 3D BioprintingSolutions business in cooperation with the other Russian and foreign scientists established the new approach of bioprinting that permits to produce 3D- biological things without the usage of layer-by-layer technique and magnetic labels. This new approach was established with the contribution from the Joint Institute for High Temperatures of the Russian Academy of Sciences (JIHT RAS). .

“During the period from 2010 to 2017, a series of unique experimental studies were carried out aboard the Russian Orbital Segment of the International Space Station at the experimental setup “CoulombCrystal”. The main element of that device is an electromagnet that creates a special inhomogeneous magnetic field in which the structures of the diamagnetic particles (they are magnetized against the direction of the magnetic field) can be formed in the microgravity conditions,” as discussed by one of the authors, Mikhail Vasiliev, head of lab of dirty plasma diagnostics in JIHT RAS. .

In their speculative research study, the JIHT scientists explained how little charged particles act in the electromagnetic field of a unique shape under the microgravity conditions, consisting of absolutely no gravity. In addition, the scientists established a mathematical design of this procedure based upon the approaches of molecular characteristics. These results describe how to acquire uniform and prolonged three-dimensional structures consisting of the thousands of the particles. .

The traditional approaches of magnetic 3D-bioprinting had a number of restrictions related to the gravity. To decrease the impact of the gravitational forces, one can increase the power of magnets that manage the electromagnetic field. However, this will make complex the bioprinter significantly. The 2nd way is to decrease the gravity. A group of scientists from 3D BioprintingSolutions utilized this technique. The new approach is called “formative three-dimensional biofactory” and it permits you to produce three-dimensional biological structures not in layers however right away from all the sides. The scientists used the speculative information and the outcomes of the mathematical modeling gotten by the JIHT RAS scientists to control the shape of such structures. .

“The results of the Coulomb crystal experiment on the study of the formation of the spatially ordered structures led to the development of a new method for the formative 3D-biofactory of the tissue-like structures based on the programmable self-assembly of the living tissues and organs under the conditions of gravity and microgravity by means of an inhomogeneous magnetic field,” summed up the author. .

Bioprinters based upon the new technology application will be able to produce different biological constucts that can be utilized, for instance, to price quote the negative impacts of the space radiation on the health of the astronauts in the long-lasting space objectives. In addition to that, according to the authors, this technology will be able to bring back the function of the broken tissues and organs in the future. .


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